Litronesib

• UNSPSC Description:

  Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity[1].

• Target Antigen:

  Kinesin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Litronesib.html

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  CC(C)(C)C(N1[C@@](C2=CC=CC=C2)(CNS(CCNCC)(=O)=O)SC(NC(C(C)(C)C)=O)=N1)=O

• Molecular Weight:

  511.70

• References & Citations:

  [1]Ye XS, et al. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol Cancer Ther. 2015 Nov;14(11):2463-72.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 2

• CAS Number:

  910634-41-2