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Orexin B, rat, mouse (TFA)

CAT: 0804-HY-P1349A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1349A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation[1][2][3].
Product Name Alternative
Rat orexin B (TFA) ; Orexin B (mouse) (TFA)
UNSPSC
12352209
Target
Orexin Receptor (OX Receptor)
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/orexin-b-rat-mouse-tfa.html
Purity
98.68
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(CCC3)C(CNC([C@H]4N(CCC4)C([C@@H](N)CCCNC(N)=N)=O)=O)=O.O=C(O)C(F)(F)F
Molecular Formula
C128H216F3N45O36S
Molecular Weight
3050.42
References & Citations
[1]Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83 (5) :695-7.|[2]Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92 (4) :573-85.|[3]Ziolkowska A, et al. Orexin B inhibits proliferation and stimulates specialized function of cultured rat calvarial osteoblast-like cells. Int J Mol Med. 2008;22 (6) :749-755.|[4]Zhang G, et al. Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina. Neuropharmacology. 2018;133:38-50.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
OX2 Receptor

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