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Landiolol

CAT: 0804-HY-100607Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100607Size:1 Each
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Description
Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury[1][2][3].
CAS Number
133242-30-5
Product Name Alternative
ONO1101
UNSPSC
12352005
Target
Adrenergic Receptor; Calcium Channel; Potassium Channel; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/landiolol.html
Smiles
O=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2
Molecular Formula
C25H39N3O8
Molecular Weight
509.59
References & Citations
[1]Tomihari M, et al. Propranolol and landiolol inhibit cell proliferation enhanced by noradrenaline in human lung adenocarcinoma cells. Biomed Res. 2024;45 (6) :253-259.|[2]Kiyonaga N, et al. Effects of Landiolol in Lipopolysaccharide-Induced Acute Kidney Injury in Rats and In Vitro. Shock. 2019 Nov;52 (5) :e117-e123.|[3]Shibata S, et al. Direct effects of esmolol and landiolol on cardiac function, coronary vasoactivity, and ventricular electrophysiology in guinea-pig hearts. J Pharmacol Sci. 2012;118 (2) :255-65.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Inwardly rectifying potassium channel; L-type calcium channel; β adrenergic receptor

Alternative Products

CatalogName
RM-L011400-01Landiolol
BUP10427-01Landiolol hydrochloride
453534Landiolol-D4
326680Landiolol HCl

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