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Nodosin

CAT: 0804-HY-N3181-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3181-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nodosin is an orally active diterpenoid compound that can be isolated from Isodon serra. Nodosin can inhibit the proliferation and induce cell cycle arrest and apoptosis of tumor cells. Nodosin can also inhibit oxidative stress, inflammatory responses, and ferroptosis. Nodosin has anti-inflammatory and anti-tumor activities[1][2][3].
CAS Number
10391-09-0
UNSPSC
12352005
Target
Apoptosis; c-Myc; Ferroptosis; GSK-3; Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2; NF-κB; Survivin; Wnt; β-catenin
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nodosin.html
Purity
98.44
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@@]([C@]2(C(C3=C)=O)C[C@H]3C1)([H])[C@@]([C@@](CC4)([H])OC2=O)(CO5)[C@](C4(C)C)([H])[C@@H]5O
Molecular Formula
C20H26O6
Molecular Weight
362.42
References & Citations
[1]Bae ES, et al. Anti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells. Biomol Ther (Seoul) . 2020 Sep 1;28 (5) :465-472.|[2]Su C, et al. Protective effects of nodosin against lipopolysaccharide-induced acute kidney injury through regulation of oxidative stress, inflammation, and ferroptosis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397 (10) :8009-8022|[3]Zhou X, et al. Effect of nodosin on accelerating hepatocyte regeneration after partial liver transplantation in rats. Organ Transplantation, 2016: 132-138.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
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