Products for Research Use Only
RegisterLogin

Rottlerin

CAT: 0804-HY-18980-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18980-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα, β, γ of 30-42 μM, PKCε, η, ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5].
CAS Number
82-08-6
Product Name Alternative
Mallotoxin; NSC 56346; NSC 94525
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Apoptosis; Autophagy; HIV; PKC; RABV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Rottlerin.html
Concentration
10mM
Purity
98.45
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4
Molecular Formula
C30H28O8
Molecular Weight
516.54
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199 (1) :93-8.|[2]Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77 (6) :460-70.|[3]Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.|[4]María Rosa López-Huertas, et al. Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. J Biol Chem. 2011 Aug 5;286 (31) :27363-77.|[5]Zoé Lama, et al. Kinase inhibitors tyrphostin 9 and rottlerin block early steps of rabies virus cycle. Antiviral Res. 2019 Aug;168:51-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV-1; PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCζ; PKCη

Alternative Products

CatalogName
407481Rottlerin

Popular Products