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Troleandomycin

CAT: 0804-HY-108881-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108881-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3].
CAS Number
[2751-09-9]
Product Name Alternative
Triacetyloleandomycin
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Antibiotic; Bacterial; Cytochrome P450
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/troleandomycin.html
Purity
98.58
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1[C@@]2(C[C@@H]([C@@H]([C@H]([C@@H]([C@@H](C)C(O[C@H](C)[C@H](C)[C@@](OC(C)=O)([H])[C@H]1C)=O)O[C@@]3([H])C[C@@H]([C@@H](OC(C)=O)[C@H](C)O3)OC)C)O[C@@]4([H])[C@@H]([C@H](C[C@@H](C)O4)N(C)C)OC(C)=O)C)CO2
Molecular Formula
C41H67NO15
Molecular Weight
813.97
Precautions
H302, H312, H332
References & Citations
[1]Shingen Misaka, et al. Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats. Drug Metab Pharmacokinet. 2013;28 (6) :514-8.|[2]A Honda, et al. Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis. J Biol Chem. 2001 Sep 14;276 (37) :34579-85.|[3]D J Evans, et al. Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma. Cochrane Database Syst Rev. 2001; (2) :CD002987.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP3; Macrolide

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MBS5756646Troleandomycin
TBI2227-5MGTroleandomycin, Macrolide antibiotic, Inhibits cytochrome P450

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