Benzo[c][1,8]naphthyridin-6(5H)-one

Benzo[c][1,8]naphthyridin-6(5H)-one

• CAS Number: 53439-81-9
• UNSPSC Description: Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM[1][2][3].
• Target Antigen: Adenosine Receptor; Aurora Kinase; PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/benzo-c-1-8-naphthyridin-6-5h-one.html
• Smiles: O=C1NC2=NC=CC=C2C3=CC=CC=C13
• Molecular Weight: 196.20
• References & Citations: [1]van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21.|[2]Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. |[3]Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported