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Seratrodast (Standard)

CAT: 0804-HY-B0774R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0774R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Seratrodast (Standard) is the analytical standard of Seratrodast. This product is intended for research and analytical applications. Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity[1][2][3].
CAS Number
112665-43-7
Product Name Alternative
AA 2414 (Standard)
UNSPSC
12352005
Hazard Statement
H361
Target
Ferroptosis; JNK; MDM-2/p53; Prostaglandin Receptor; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seratrodast-standard.html
Purity
98.17
Smiles
CC(C1=O)=C(C(C(C)=C1C)=O)C(C2=CC=CC=C2)CCCCCC(O)=O
Molecular Formula
C22H26O4
Molecular Weight
354.44
Precautions
H361
References & Citations
[1]Ashida, Y., et al., A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins, 1989. 38 (1) : p. 91-112.|[2]Walsh, et al. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290 (1) : p. 220-6.|[3]Hao Y, et al. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. Brain Res. 2022 Nov 15;1795:148073.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

Chemical Information

Seratrodast

Seratrodast is an organic molecular entity.

CAS Number112665-43-7
PubChem CID2449
IUPAC Name7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid
Molecular FormulaC22H26O4
Molecular Weight354.4
XLogP4.4
Topological Polar Surface Area71.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count26
Formal Charge0
Complexity633
SMILES
CC1=C(C(=O)C(=C(C1=O)C)C(CCCCCC(=O)O)C2=CC=CC=C2)C
InChI
InChI=1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)
InChIKey
ZBVKEHDGYSLCCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Seratrodast
CAS: 112665-43-7
CID: 2449
Formula: C22H26O4
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass354.18310931
Monoisotopic Mass354.18310931
Topological Polar Surface Area71.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity633
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
C3706-25Seratrodast
A18134-200Seratrodast 200mg
A18134-50Seratrodast 50mg
A18134-25Seratrodast 25mg
A18134-5Seratrodast 5mg
A18134-100Seratrodast 100mg
A18134-10Seratrodast 10mg
A18134-500Seratrodast 500mg
C16624Seratrodast (AA-2414)

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