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Seratrodast (Standard)

CAT: 0804-HY-B0774R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0774R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Seratrodast (Standard) is the analytical standard of Seratrodast. This product is intended for research and analytical applications. Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity[1][2][3].
CAS Number
112665-43-7
Product Name Alternative
AA 2414 (Standard)
UNSPSC
12352005
Hazard Statement
H361
Target
Ferroptosis; JNK; MDM-2/p53; Prostaglandin Receptor; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seratrodast-standard.html
Purity
98.17
Smiles
CC(C1=O)=C(C(C(C)=C1C)=O)C(C2=CC=CC=C2)CCCCCC(O)=O
Molecular Formula
C22H26O4
Molecular Weight
354.44
Precautions
H361
References & Citations
[1]Ashida, Y., et al., A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins, 1989. 38 (1) : p. 91-112.|[2]Walsh, et al. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290 (1) : p. 220-6.|[3]Hao Y, et al. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. Brain Res. 2022 Nov 15;1795:148073.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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Alternative Products

CatalogName
C3706-25Seratrodast
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A18134-50Seratrodast 50mg
A18134-25Seratrodast 25mg
A18134-5Seratrodast 5mg
A18134-100Seratrodast 100mg
A18134-10Seratrodast 10mg
A18134-500Seratrodast 500mg
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