Clomethiazole

CAT: 0804-HY-129105-01Size: 100 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-129105-01Size:100 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Chlormethiazole is an potent and orally active GABAA agonist[1]. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].

CAS Number

533-45-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H412

Target

Cytochrome P450; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/clomethiazole.html

Concentration

10mM

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(CCCl)SC=N1

Molecular Formula

C6H8ClNS

Molecular Weight

161.65

Precautions

H302, H315, H319, H335, H412

References & Citations

[1]Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA (A) receptors.Eur J Pharmacol. 2002 Oct 11;452 (3) :255-62.|[2]Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44 (8) :1424-30

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

CYP2

Alternative Products

Catalog	Name
GTR19155474-01	Clomethiazole
413133	Clomethiazole HCl
AR-C03189-01	Clomethiazole-d7

Clomethiazole

Alternative Products

Popular Products