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Recombinant Human CCL2, biotinylated

CAT: 0014-50186PB-1Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0014-50186PB-1Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recombinant human CCL2
CAS Number
9000-83-3
Product Name Alternative
rHuCCL2-biotin, MCP-1
Gene Name
CCL2
UniProt
P13500
Cellular Locus
Secreted
Reactivity
Human
Target Antigen
C-C motif chemokine 2
Target
CCL2ylated
Type
Protein
Applications
Migration assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). {PubMed:10529171, PubMed:10587439, PubMed:8107690, PubMed:8195247, PubMed:8627182, PubMed:9792674, PubMed:9837883}.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay of recombinant CCR2-expressing cells.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.
Specificity
CCL2ylated
Target Background
CCL2, also known as Monocyte Chemoattractant Protein-1 (MCP-1) is a small cytokine (~13kDa) that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of inflammation produced by either tissue injury or infection. It is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. To become activated, CCL2 protein has to be cleaved by metalloproteinase MMP-12. CCL2 is implicated in the pathogenesis of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCR2 and CCR4 are two cell surface receptors that bind CCL2.

UniProtKB · P13500

C-C motif chemokine 2

CCL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13500
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R4V3, Q9UDF3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bondGlycoproteinPyrrolidone carboxylic acid

Cellular component

Secreted

Domain

Signal

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