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Derrone

CAT: 0804-HY-N3737-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3737-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2].
CAS Number
76166-59-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aurora Kinase; PERK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/derrone.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C=C4
Molecular Formula
C20H16O5
Molecular Weight
336.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Hoang NT, et al. In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor. Biol Pharm Bull. 2016 Jun 1;39 (6) :935-45.|[2]Kang MJ, et al. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells. PLoS One. 2019 Jun 19;14 (6) :e0218659.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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