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SDUY038

CAT: 0804-HY-159489Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159489Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SDUY038 is a SHP2 allosteric inhibitor, with an IC50 of 1.2 μM and KD of 0.29 μM, respectively. SDUY038 exhibits pan-antitumor activity (IC50 = 7-24 μM) by suppressing pERK expression. SDUY038 exhibits t1/2 of 3.95 h by oral administration[1].
CAS Number
2892720-11-3
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sduy038.html
Smiles
O=C(N1CCC(C)(CC1)N)C2=CC=C(SC3=C(Cl)C(Cl)=CC=C3)O2
Molecular Formula
C17H18Cl2N2O2S
Molecular Weight
385.31
References & Citations
[1]Chengchun Zhu, et al. Design, Synthesis and Antitumor Activity of a Novel Class of SHP2 Allosteric Inhibitors with a Furanyl Amide-Based Scaffold. J Med Chem. 2024 Aug 8;67 (15) :13305-13323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19238385-01SDUY038

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