Rucaparib phosphate

• Background:

  Rucaparib is a PARP1, PARP2 and PARP3 inhibitor and inhibits PARP-mediated DNA repair (1). It is being developed for ovarian, prostate and bladder cancers (2, 3).

• Description:

  PARP Inhibitor

• Product Name Alternative:

  8-fluoro-1,3,4,5-tetrahydro-2-[4-[ (methylamino) methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one, phosphate; AG-14699; PF01367338

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | PARP Inhibitors

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Yellow powder

• Solubility:

  May be dissolved in DMSO (25 mg/ml)

• Molecular Formula:

  C19H18FN3O * H3PO4

• Molecular Weight:

  421.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. https://pubchem.ncbi.nlm.nih.gov/compound/rucaparib 2. Dockery L.E., Gunderson C.C., and Moore K.N. (2017) Onco Target Ther. 10: 3029-3037. 3. Syed Y.Y. (2017) Drugs. 77(5): 585-592.

• CAS Number:

  459868-92-9