Rucaparib phosphate

CAT: 0400-SIH-580-5MGSize: 5 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-580-5MGSize:5 mg
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Background
Rucaparib is a PARP1, PARP2 and PARP3 inhibitor and inhibits PARP-mediated DNA repair (1). It is being developed for ovarian, prostate and bladder cancers (2, 3).
Description
PARP Inhibitor
CAS Number
459868-92-9
Product Name Alternative
8-fluoro-1,3,4,5-tetrahydro-2-[4-[ (methylamino) methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one, phosphate; AG-14699; PF01367338
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | PARP Inhibitors
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Yellow powder
Solubility
May be dissolved in DMSO (25 mg/ml)
Molecular Formula
C19H18FN3O * H3PO4
Molecular Weight
421.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. https://pubchem.ncbi.nlm.nih.gov/compound/rucaparib 2. Dockery L.E., Gunderson C.C., and Moore K.N. (2017) Onco Target Ther. 10: 3029-3037. 3. Syed Y.Y. (2017) Drugs. 77(5): 585-592.

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