P7C3

CAT: 0400-SIH-571-25MGSize: 25 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-571-25MGSize:25 mg
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Background
P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity (1). Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis (2). Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson's disease (3). Restores hippocampal neurogenesis in a mouse model of Down Syndrome (4). The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD (5). Active in vivo.
Description
NAMPT activator
CAS Number
301353-96-8
Product Name Alternative
1- (3,6-dibromo-9H-carbazol-9-yl) -3- (phenylamino) propan-2-ol; AK34095
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Apoptosis | Neuroscience | Neurodegeneration | Alzheimer's Disease | Parkinson's Disease | Cardiovascular System | Angiogenesis | Cardiovascular Growth Factors | VEGF | VEGF Receptors | Atherosclerosis | Diabetes Associated | Cancer | Cell Cycle | p53 Pathway
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (40 mg/ml)
Molecular Formula
C21H18Br2N2O
Molecular Weight
474.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. AA Pieper et al. Cell 2010 142:39 2. T Tesla et al. Proc. Natl. Acad. Sci. USA 2012 109:17016 3. H De Jesus-Cortes et al. Proc. Natl. Acad. Sci. USA 2012 109:17010 4. SE Latchney et al. Neurosci. Lett. 2015 591:86 5. G Wang et al. Cell 2014 158:1324

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