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Mycophenolate mofetil

CAT: 0400-SIH-568-250MGSize: 250 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-568-250MGSize:250 mg
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Background
Mycophenolate mofetil is an immunosuppressive agent useful in prevention of organ allograft rejection (1). It is metabolized to mycophenolic acid in vivo, which acts by inhibiting the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). It also inhibits IL-2-dependent T cell proliferation (4), and microglial and astrocytic activation reducing cell death after neuronal injury (5). It also prevents neuroinflammation.
Description
Inosine monophosphate dehydrogenase inhibitor
CAS Number
128794-94-5
Product Name Alternative
6- (1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl) -4-methyl-4-hexenoic acid 2- (4-morpholinyl) ethyl ester
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Immunology | Autoimmune | Adaptive Immunity | B Cells | Neuroscience | Neurodegeneration | Cell Markers | Glial Markers | Microglia Markers | Astrocyte Markers
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (40 mg/ml); or ethanol (4 mg/ml)
Molecular Formula
C23H31NO7
Molecular Weight
433.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Allison A.C., and Eugui, E.M. (1996) Clin. Transplant. 10:77. 2. Jonsson C.A., et al., (2002) Cell. Immunol. 216:93. 3. Allison A.C., et al., (1993) Ann. NY Acad. Sci. 696:63. 4. Quemeneur J., et al., (2002) J. Immunol. 169:2747 5. Ebrahimi F., et al., (2012) J. Neuroinflammation 9:89.

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T6293-01Mycophenolate Mofetil

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