Bexarotene

• Background:

  Bexarotene is a highly potent and selective retinoid X receptor (RXR) agonist (1). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma (2) Causes complete regression of mammary carcinoma (3). Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability (4). Reverses apoE4-driven brain pathology and behavioral deficits in vivo (5).

• Description:

  Retinoid RXR agonist

• Product Name Alternative:

  SR 11247, Targretin, 4-[1- (5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl) ethenyl]benzoic acid

• UNSPSC:

  41116105

• Type:

  Agonist

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | Neuroscience | Neurodegeneration | Alzheimer's Disease | Cancer | Cancer Growth Inhibitors | Amyloid

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.01

• Format:

  White powder

• Solubility:

  Soluble in DMSO (60 mg/ml) or ethanol (warm, 10 mg/ml)

• Molecular Formula:

  C24H28O2

• Molecular Weight:

  348.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. MF Boehm et al. J. Med. Chem. 1995 38:3146 2. R Gniadecki et al. Br. J. Dermatol. 2007 157:433 3. ED Bischoff et al. Cancer Res. 1998 58:479 4. PE Cramer et al. Science 2012 335:1503 5. A Boehm-Cagan and DM Michaelson J. Neurosci. 2014 34:7293

• CAS Number:

  153559-49-0