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Bexarotene

CAT: 0400-SIH-535-100MGSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-535-100MGSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bexarotene is a highly potent and selective retinoid X receptor (RXR) agonist (1). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma (2) Causes complete regression of mammary carcinoma (3). Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability (4). Reverses apoE4-driven brain pathology and behavioral deficits in vivo (5).
Description
Retinoid RXR agonist
CAS Number
153559-49-0
Product Name Alternative
SR 11247, Targretin, 4-[1- (5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl) ethenyl]benzoic acid
UNSPSC
41116105
Type
Agonist
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | Neuroscience | Neurodegeneration | Alzheimer's Disease | Cancer | Cancer Growth Inhibitors | Amyloid
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.1
Format
White powder
Solubility
Soluble in DMSO (60 mg/ml) or ethanol (warm, 10 mg/ml)
Molecular Formula
C24H28O2
Molecular Weight
348.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. MF Boehm et al. J. Med. Chem. 1995 38:3146 2. R Gniadecki et al. Br. J. Dermatol. 2007 157:433 3. ED Bischoff et al. Cancer Res. 1998 58:479 4. PE Cramer et al. Science 2012 335:1503 5. A Boehm-Cagan and DM Michaelson J. Neurosci. 2014 34:7293

Alternative Products

CatalogName
A8380-50Bexarotene

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