Galantamine Hydrobromide

• Background:

  Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors (1,2). It prevents β-amyloid-induced apoptosis in SH-SY5Y (3). Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice (4,5).

• Description:

  Cholinesterase Inhibitor

• Product Name Alternative:

  Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro (4,3,2-efg) (2) benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurodegeneration | Alzheimer's Disease | Cancer | Apoptosis

• Purity:

  >97% (HPLC) ; NMR (Conforms)

• Weight:

  0.02

• Format:

  White powder

• Solubility:

  Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)

• Molecular Formula:

  C17H22BrNO3

• Molecular Weight:

  368.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. M Racchi et al. Pharmacol. Res. 2004 50:441 2. M Samochocki et al. J. Pharmacol. Exp. Ther. 2003 305:1024 3. E Arias et al. Neuropharmacology 2004 46:103 4. K Rockwood et al. J. Neurol. Neurosurg. Psychiatry 2001 71:589 5. S Chen et al. Curr. Neuropharmacol. 2007 5:127

• CAS Number:

  1953-04-4