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Galantamine Hydrobromide

CAT: 0400-SIH-530-100MGSize: 100 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-530-100MGSize:100 mg
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Background
Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors (1,2). It prevents β-amyloid-induced apoptosis in SH-SY5Y (3). Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice (4,5).
Description
Cholinesterase Inhibitor
CAS Number
1953-04-4
Product Name Alternative
Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro (4,3,2-efg) (2) benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Cancer | Apoptosis
Purity
>97% (HPLC) ; NMR (Conforms)
Weight
0.1
Format
White powder
Solubility
Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Molecular Formula
C17H22BrNO3
Molecular Weight
368.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. M Racchi et al. Pharmacol. Res. 2004 50:441 2. M Samochocki et al. J. Pharmacol. Exp. Ther. 2003 305:1024 3. E Arias et al. Neuropharmacology 2004 46:103 4. K Rockwood et al. J. Neurol. Neurosurg. Psychiatry 2001 71:589 5. S Chen et al. Curr. Neuropharmacol. 2007 5:127

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