Terazosin

• Background:

  Terazosin (TZ) which is marketed as an alpha1-adrenergic receptor antagonist, has been shown to alleviate organ damaged and increase survival in rodent models of sepsis and stroke in vivo (1). It inhibits apoptosis in macrophages by activation of Pgk1 and Hsp90 (1).

• Description:

  Alpha adrenergic antagonist, and Hsp90 Activator

• Product Name Alternative:

  1- (4-Amino-6,7-dimethoxy-2-quinazolinyl) -4-[ (tetrahydro-2-furanyl) carbonyl]piperazine

• UNSPSC:

  41116105

• Type:

  Antagonist

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Neuroscience | Neurotransmitter Receptors | Alpha-2 Adrenergic Receptors

• Purity:

  >98%

• Weight:

  0.1

• Format:

  White to off-white solid

• Solubility:

  Soluble to 20mg/ml in warm water

• Molecular Formula:

  C19H25N5O4·HCl

• Molecular Weight:

  423.89

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Chen X., et al. (2015) Nature Chem Biol. 11:19-25. 2. Hancock A.A., et al. (1995) J Recept Signal Transduct Res. 15: 863. 3. Kyncl J.J. (1986) Am J Med. 80:12.

• CAS Number:

  63074-08-8