LH 846

• Background :

  LH 846 is a potent and selective inhibitor of Casein Kinase CK1δ. Specifically, it inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. CK1δ is a known regulator of circadian rhythm.

• Description :

  Casein kinase 1d inhibitor

• Product Name Alternative :

  LH846, LH-846, N- (5-Chloro-6-methyl-2-benzothiazolyl) benzeneacetamide

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling

• Purity :

  ≥98% (HPLC)

• Weight :

  0.025

• Format :

  White to beige powder

• Solubility :

  Soluble to 100 mM in DMSO

• Molecular Formula :

  C16H13ClN2OS

• Molecular Weight :

  316.8

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611.

• CAS Number :

  639052-78-1