Axitinib

• Background:

  Axitinib is a potent and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. It has also been shown to inhibit PDGFR-β and c-Kit.

• Description:

  VEGFR kinase inhibitor

• Product Name Alternative:

  AG-013736, N-Methyl-2- ((3- ((1E) -2- (pyridin-2-yl) ethenyl) -1H-indazol-6-yl) sulfanyl) benzamide, N-Methyl-[[3[ (1E) -2- (2-pyridinyl) ethenyl]-1H-indazol-6-yl]thio]-benzamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cardiovascular System | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (HPLC)

• Weight:

  0.01

• Format:

  White to tan powder

• Solubility:

  Soluble to 25 mM in DMSO

• Molecular Formula:

  C22H18N4OS

• Molecular Weight:

  386.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Hu-Lowe D.D., et al. (2008) Clin. Cancer Res: J. Am. Ass. Cancer Res. 14(22): 7272–7283.

• CAS Number:

  319460-85-0