SU 4312

• Background:

  SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases, including VEGFR-2 (Flk-1, KDR).

• Description:

  VEGFR, PDGFR kinase inhibitor

• Product Name Alternative:

  3-[[4- (dimethylamino) phenyl]methylene]-1,3-dihydro-2H-indol-2-one

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cardiovascular System | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (HPLC)

• Weight:

  0.005

• Format:

  Orange solid

• Solubility:

  Soluble in DMSO (25 mg/ml)

• Molecular Formula:

  C17H16N2O

• Molecular Weight:

  264.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Zaman G.J., et al. (1999) Biochem. Pharm. 57(1): 57–64. 2. Shimotake J., Derugin N., Wendland M., Vexler Z.S., & Ferriero D.M. (2010) Stroke. 41(2): 343–349. 3. Schultheiss C., et al. (2006) Angiogenesis. 9(2): 59–65.

• CAS Number:

  5812-07-7