RegisterLogin

SB203580

CAT: 0400-SIH-474-25MGSize: 25 mgDry Ice: NoHazardous: No
CAT#: SIH-474-25MGSize: 25 mg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1Product image 2
1 / 2
Background
SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.
Description
P38 MAP kinase inhibitor
CAS Number
152121-47-6
Product Name Alternative
4- (4-Fluorophenyl) -2- (4-methylsulfinylphenyl) -5- (4-pyridyl) 1H-imidazole
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
White to off-white powder
Solubility
Soluble in DMSO (50 mg/ml)
Molecular Formula
C21H16FN3OS
Molecular Weight
377.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054. 2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589. 3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.

Related Products

CatalogName

Alternative Products

CatalogName
S1863-5mgSB203580
MBS808174-01SB203580
MBS576713SB203580
S1863-100mgSB203580
S1863-1mgSB203580
S1863-25mgSB203580
CST 5633SSB203580
inh-sb20-5SB203580
C07496-01Adezmapimod (SB203580)
C16092-01Adezmapimod (SB203580)

Popular Products