Roscovitine

• Background:

  Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating. It also stimulates neuronal growth.

• Description:

  P34/cdc2 inhibitor

• Product Name Alternative:

  2- (R) -[[9- (1-Methylethyl) -6-[ (phenylmethyl) amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2- (R) -[ (1-ethyl) -2-hydroxyethylamino]-9-isopropylpurine, 2 (R) - (1-Ethyl-2-hydroxyethylamino) -6-benzylamino-9-isopropylpurine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Protein Phosphorylation | Cdks | Neuroscience | Neurodegeneration | Neurogenesis

• Purity:

  >99% (TLC and HPLC) ; NMR (Conforms)

• Weight:

  0.002

• Format:

  White to off-white solid

• Solubility:

  May be dissolved in ethanol (10mg/mL); or DMSO (10mg/mL, warm)

• Molecular Formula:

  C19H26N6O

• Molecular Weight:

  354.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.

• CAS Number:

  186692-46-6