Roscovitine

CAT: 0400-SIH-472-10MGSize: 10 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-472-10MGSize:10 mg
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Background
Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating. It also stimulates neuronal growth.
Description
P34/cdc2 inhibitor
CAS Number
186692-46-6
Product Name Alternative
2- (R) -[[9- (1-Methylethyl) -6-[ (phenylmethyl) amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2- (R) -[ (1-ethyl) -2-hydroxyethylamino]-9-isopropylpurine, 2 (R) - (1-Ethyl-2-hydroxyethylamino) -6-benzylamino-9-isopropylpurine
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Protein Phosphorylation | Cdks | Neuroscience | Neurodegeneration | Neurogenesis
Purity
>99% (TLC and HPLC) ; NMR (Conforms)
Weight
0.01
Format
White to off-white solid
Solubility
May be dissolved in ethanol (10mg/mL); or DMSO (10mg/mL, warm)
Molecular Formula
C19H26N6O
Molecular Weight
354.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.

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