PX 866

• Background:

  PX 866 is a wortmannin derivative that inhibits purified phosphoinositide (PtdIns)-3-kinase and. PX 866 has been shown to inhibit tumor growth by blocking the PI 3-kinase pathway and cell motility.

• Description:

  PI 3-Kinase inhibitor

• Product Name Alternative:

  (1E, ​4S, ​4aR, ​5R, ​6aS, ​9aR) -​5-​ (acetyloxy) -​1-​[ (di-​2-​propen-​1-​ylamino) methylene]-​4, ​4a, ​5, ​6, ​6a, ​8, ​9, ​9a-​octahydro-​11-​hydroxy-​4-​ (methoxymethyl) -​4a, ​6a-​dimethyl-​cyclopenta[5, ​6]naphtho[1, ​2-​c]pyran-​2, ​7, ​10 (1H) -​trione

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98%

• Weight:

  0.005

• Format:

  Crystalline solid

• Solubility:

  Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water

• Molecular Formula:

  C29H35NO8

• Molecular Weight:

  525.6

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ihle N.T., et al. (2004). Mol. Cancer. Ther. 3(7): 763–772. 2. Gwak H.S., et al. (2011). Int. J. Cancer. 128(4): 787–796.

• CAS Number:

  502632-66-8