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PP2

CAT: 0400-SIH-470-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-470-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PP2 is a selective inhibitor of Src-family tyrosine kinases. PP2 has been shown to inhibit Lck, FynT, and phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). PP2 displays > 10000-fold selectivity over ZAP-70 and JAK2.
Description
Src kinase inhibitor
CAS Number
172889-27-9
Product Name Alternative
3- (4-chlorophenyl) 1- (1,1-dimethylethyl) -1H-pyrazolo[3,4-d]pyrimidin-4-amine
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white solid
Solubility
May be dissolved in DMSO (25mg/mL); or ethanol (3mg/mL, warm)
Molecular Formula
C15H16ClN5
Molecular Weight
301.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

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