PP1

• Background:

  PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.

• Description:

  Src kinase inhibitor

• Product Name Alternative:

  1- (1,1-Dimethylethyl) -1- (4-methylphenyl) -1H-pyrazolo[3,4-d]pyrimidin-4-amine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥ 98% (TLC)

• Weight:

  0.025

• Format:

  Tan solid

• Solubility:

  Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol

• Molecular Formula:

  C16H19N5

• Molecular Weight:

  281.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

• CAS Number:

  172889-26-8