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PD98059

CAT: 0400-SIH-466-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-466-25MGSize:25 mg
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Background
PD98059 is a potent, selective and reversible inhibitor of mitogen-activated protein kinase kinase (MAPKK/ MEK-1) activation. Specifically, it binds to the inactive form of MAPKK, blocking its activation, causing inhibition of phosphorylation and the activation of MAP kinase. It has been shown to enhance self-renewal of embryonic stem cells. PD98059 is cell permeable inhibitor.
Description
MEK kinase inhibitor
CAS Number
167869-21-8
Product Name Alternative
2- (2-Amino-3-methoxyphenyl) -4H-1-benzopyran-4-one, PD98059
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.025
Format
Pale yellow solid
Solubility
May be dissolved in DMSO (6mg/mL)
Molecular Formula
C16H13NO3
Molecular Weight
267.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., & Saltiel A.R. (1995) J. Biol. Chem. 270(46): 27489–27494. 2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032. 3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689.

Alternative Products

CatalogName
A1663-100PD98059

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