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Nilotinib

CAT: 0400-SIH-463-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-463-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nilotinib is a potent and selective Bcr/Abl tyrosine kinase inhibitor, as well as, an inhibitor of JAK2/STAT5, and MDM2 at the post-translational level. Nilotinib shows antiproliferative and antitumor effects in vivo.
Description
BCR-ABL kinase inhibitor
CAS Number
641571-10-0
Product Name Alternative
4-methyl-N-[3- (4-methylimidazol-1-yl) -5- (trifluoromethyl) phenyl]-3-[ (4-pyridin-3-ylpyrimidin-2-yl) amino]benzamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥99%
Weight
0.005
Format
Crystalline powder
Solubility
Soluble in DMSO (50 mg/ml), chloroform, DMF (~3 mg/ml), water(very poorly soluble, maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility), and ethanol(very poorly soluble)
Molecular Formula
C28H22F3N7O
Molecular Weight
529.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gallipoli P., et al. (2014) Blood. 2. Zhang H., Gu L., Liu T., Chiang K.Y., & Zhou M. (2014) PloS One. 9(6): e100960.

Alternative Products

CatalogName
HY-10159-01Nilotinib

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