Lestaurtinib

• Background :

  Lestaurtinib is potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor. Specifically, it prevents STAT5 phosphorylation. Lestaurtinib exhibits antiproliferative activity in vitro.

• Description :

  FLT3, TrkA kinase inhibitor

• Product Name Alternative :

  KT5555, CEP-701, (9S,10S,12R) -2,3,9,10,11,12-Hexahydro-10-hydroxy-10- (hydroxymethyl) -9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity :

  ≥98% (HPLC)

• Weight :

  0.001

• Format :

  White powder

• Solubility :

  Soluble to 100 mM in DMSO and to 25 mM in ethanol

• Molecular Formula :

  C26H21N3O4

• Molecular Weight :

  439.5

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Weisel K.C., et al. (2007) Ann. NY Acad. Sci. 1106: 190–196. 2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.

• CAS Number :

  111358-88-4