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K252B

CAT: 0400-SIH-456-1MGSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-456-1MGSize:1 mg
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Background
K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
Description
Kinase inhibitor
CAS Number
99570-78-2
Product Name Alternative
(9S, ​10R, ​12R) -​2, ​3, ​9, ​10, ​11, ​12-​hexahydro-​10-​hydroxy-​9-​methyl-​1-​oxo-​9, ​12-​epoxy-​1H-​diindolo[1, ​2, ​3-​fg:3', ​2', ​1'-​kl]pyrrolo[3, ​4-​i][1, ​6]benzodiazocine-​10-​carboxylic acid
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.001
Format
White solid
Solubility
Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)
Molecular Formula
C26H19N3O5
Molecular Weight
453.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071. 2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969. 3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.

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