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H89

CAT: 0400-SIH-452-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-452-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
H89 Dihydrochloride is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). It has also been shown to inhibit CaM kinase II, casein kinase I and MYLK, as well as, Rsk-2, MSK1, Akt1, PKC µ, Rock-2, p70 S6 kinase α. H89 Dihydrochloride can induce apoptosis. It is cell permeable.
Description
PKA inhibitor
CAS Number
127243-85-0
Product Name Alternative
N-[2- (p-Bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide . 2HCl
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
99% (TLC)
Weight
0.005
Format
White to off-white solid
Solubility
Soluble in DMSO (25 mg/ml), methanol and 50% ethanol/water (20 mg/ml)
Molecular Formula
C20H22BrCl2N3O2S
Molecular Weight
519.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Bouschet, T., (2003) J. Biol. Chem. 278(7): 4778–4785. 2. Findik D., Song Q., Hidaka H., & Lavin M. (1995) J. Cell. Biochem. 57(1): 12–21. 3. Davies S. P., Reddy H., Caivano M., & Cohen P. (2000) Biochem. J. 351(Pt 1): 95–105.

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