GF109203X

• Background :

  GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.

• Description :

  PKC kinase inhibitor

• Product Name Alternative :

  2-[1- (3-Dimethylaminopropyl) indol-3-yl]-3- (indol-3-yl) maleimide, 3- (N-[Dimethylamino]propyl-3-indolyl) -4- (3-indolyl) maleimide, 3-[1-[3- (Dimethylamino) propyl]1H-indol-3-yl]-4- (1Hindol-3-yl) 1H-pyrrole-2,5dione, Bisindolylmaleimide I

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity :

  ≥98% (TLC)

• Weight :

  0.01

• Format :

  Red solid

• Solubility :

  Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well)

• Molecular Formula :

  C25H24N4O2

• Molecular Weight :

  412.5

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781. 2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002. 3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180. 4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.

• CAS Number :

  133052-90-1