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Genistein

CAT: 0400-SIH-446-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-446-50MGSize:50 mg
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Background
Genistein has a wide range of biological actions. It is an inhibitor of tyrosine protein kinase, including epidermal growth factor receptor kinase. It also inhibits DNA topoisomerase and α-glucosidase. It produces cell cycle arrest and apoptosis, and inhibits endocytosis, as well as, inhibits insulin-induced glucose uptake in adipocytes.
Description
Tyrosine kinase inhibitor
CAS Number
446-72-0
Product Name Alternative
4',5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3- (4-hydroxyphenyl) -4H-1-benzopyran-4-one, 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3- (4-hydroxyphenyl) -4H-1-benzopyran-4-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.05
Format
Creamy off-white solid
Solubility
Soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water
Molecular Formula
C15H10O5
Molecular Weight
270.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Akiyama T., et al. (1987) J Biol. Chem. 262(12): 5592–5595. 2. Bazuine M., van den Broek P.J.A., & Maassen J. A. (2005) Biochem. Biophys. Res. Comm. 326(2): 511–514. 3. Linassier C., Pierre M., Le Pecq J.B., & Pierre J. (1990) Biochem. Pharm. 39(1): 187–193. 4. Dean N.M., Kanemitsu M., & Boynton A.L. (1989) Biochem. Biophys. Res. Comm. 165(2): 795–801.

Alternative Products

CatalogName
A2198-100Genistein

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