Genistein

• Background:

  Genistein has a wide range of biological actions. It is an inhibitor of tyrosine protein kinase, including epidermal growth factor receptor kinase. It also inhibits DNA topoisomerase and α-glucosidase. It produces cell cycle arrest and apoptosis, and inhibits endocytosis, as well as, inhibits insulin-induced glucose uptake in adipocytes.

• Description:

  Tyrosine kinase inhibitor

• Product Name Alternative:

  4',5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3- (4-hydroxyphenyl) -4H-1-benzopyran-4-one, 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3- (4-hydroxyphenyl) -4H-1-benzopyran-4-one

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (HPLC)

• Weight:

  0.05

• Format:

  Creamy off-white solid

• Solubility:

  Soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water

• Molecular Formula:

  C15H10O5

• Molecular Weight:

  270.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Akiyama T., et al. (1987) J Biol. Chem. 262(12): 5592–5595. 2. Bazuine M., van den Broek P.J.A., & Maassen J. A. (2005) Biochem. Biophys. Res. Comm. 326(2): 511–514. 3. Linassier C., Pierre M., Le Pecq J.B., & Pierre J. (1990) Biochem. Pharm. 39(1): 187–193. 4. Dean N.M., Kanemitsu M., & Boynton A.L. (1989) Biochem. Biophys. Res. Comm. 165(2): 795–801.

• CAS Number:

  446-72-0