Gefitinib

• Background:

  Gefitinib is a selective inhibitor of EGFR tyrosine kinase by blocking EGFR autophosphorylation.

• Description:

  EGFR Kinase inhibitor

• Product Name Alternative:

  N- (3-chloro-4-fluorophenyl) -7-methoxy-6- (3-morpholin-4-ylpropoxy) quinazolin-4-amine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  >99%

• Weight:

  0.05

• Format:

  Solid

• Solubility:

  Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C)

• Molecular Formula:

  C22H24ClFN4O3

• Molecular Weight:

  446.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ciardiello F., et al. (2000) Clin. Cancer Res. 6(5): 2053–2063.

• CAS Number:

  184475-35-2