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Dasatinib

CAT: 0400-SIH-440-25MGSize: 25 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-440-25MGSize:25 mg
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Background
Dasatinib is a dual Src and Abl kinase inhibitor with ∼325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner.
Description
Kinase inhibitor
CAS Number
302962-49-8
Product Name Alternative
N- (2-chloro-6-methylphenyl) -2-[[6-[4- (2-hydroxyethyl) piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98%
Weight
0.025
Format
Crystalline solid
Solubility
Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly )
Molecular Formula
C22H26ClN7O2S
Molecular Weight
488
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287.

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