Dasatinib

• Background:

  Dasatinib is a dual Src and Abl kinase inhibitor with ∼325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner.

• Description:

  Kinase inhibitor

• Product Name Alternative:

  N- (2-chloro-6-methylphenyl) -2-[[6-[4- (2-hydroxyethyl) piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98%

• Weight:

  0.025

• Format:

  Crystalline solid

• Solubility:

  Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly )

• Molecular Formula:

  C22H26ClN7O2S

• Molecular Weight:

  488

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287.

• CAS Number:

  302962-49-8