Dasatinib

• Background :

  Dasatinib is a dual Src and Abl kinase inhibitor with ∼325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner.

• Description :

  Kinase inhibitor

• Product Name Alternative :

  N- (2-chloro-6-methylphenyl) -2-[[6-[4- (2-hydroxyethyl) piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity :

  ≥98%

• Weight :

  0.025

• Format :

  Crystalline solid

• Solubility :

  Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly )

• Molecular Formula :

  C22H26ClN7O2S

• Molecular Weight :

  488

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287.

• CAS Number :

  302962-49-8