CHIR99021

CHIR99021

• Background: CHIR99021 is a potent and highly selective glycogen synthase kinase 3 (GSK-3) inhibitor. It also promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization.
• Description: GSK3β kinase inhibitor
• Product Name Alternative: CT99021 , 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
• CAS Number: 252917-06-9
• UNSPSC: 41116105
• Source: Synthetic
• Purity: ≥98% (HPLC); NMR (Conforms)
• Weight: 0.001
• Format: White to light brown solid
• Solubility: May be dissolved in DMSO (25mg/mL, warm)
• Molecular Formula: C22H18Cl2N8
• Molecular Weight: 465.3
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Ye S., et al. (2012) PloS One 7(4): e35892. 2. Ring D. B., et al. (2003). Diabetes. 52(3): 588–595.