CHIR99021

• Background:

  CHIR99021 is a potent and highly selective glycogen synthase kinase 3 (GSK-3) inhibitor. It also promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization.

• Description:

  GSK3β kinase inhibitor

• Product Name Alternative:

  CT99021 , 6-[[2-[[4- (2,4-Dichlorophenyl) -5- (5-methyl-1H-imidazol-2-yl) -2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (HPLC) ; NMR (Conforms)

• Weight:

  0.001

• Format:

  White to light brown solid

• Solubility:

  May be dissolved in DMSO (25mg/mL, warm)

• Molecular Formula:

  C22H18Cl2N8

• Molecular Weight:

  465.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ye S., et al. (2012) PloS One 7(4): e35892. 2. Ring D. B., et al. (2003). Diabetes. 52(3): 588–595.

• CAS Number:

  252917-06-9