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6BIO

CAT: 0400-SIH-422-5MGSize: 5 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-422-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
6BIO is an inhibitor of phosphoinositide-dependent kinase 1 (PDK1), and a potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β). It maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway.
Description
PDK1 kinase inhibitor
CAS Number
667463-62-9
Product Name Alternative
(2'Z,3'E) -6-Bromoindirubin-3′-oxime, 6-BIO, 6BIO, (3Z) -6-Bromo-3-[ (3E) -3- (hydroxyimino) -1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
≥98% (HPLC)
Weight
0.005
Format
Dark red solid
Solubility
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Molecular Formula
C16H10BrN3O2
Molecular Weight
356.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Valerio A., et al. (2011) J. Neurochem. 116(6): 1148–1159. 2. Yasuhara R., et al. (2010) J. Biol. Chem. 285(1): 317–327. 3. Meijer L., et al. (2003) Chem. & Bio. 10(12): 1255–1266.

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