PHA-665752

• Background:

  PHA 665752 is a potent and selective MET kinase, ATP-competitive inhibitor. It has been studied as an antitumor agent because it has been seen to inhibit tumorigenicity and angiogenesis in mouse lung cancer xenografts.

• Description:

  MET kinase inhibitor

• Product Name Alternative:

  (2R) -1-[[5-[ (Z) -[5-[[ (2,6-Dichlorophenyl) methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2- (1-pyrrolidinylmethyl) pyrrolidine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  >98

• Weight:

  0.025

• Format:

  Yellow solid

• Solubility:

  Soluble to 100 mM in DMSO.

• Molecular Formula:

  C32H34Cl2N4O4S

• Molecular Weight:

  641.61

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Puri N., Khramtsov A., Ahmed S., Nallasura V., Hetzel J., Jagadeeswaran R., et al. (2007) Cancer Res. 3529-34.

• CAS Number:

  477575-56-7