Lenalidomide

CAT: 0400-SIH-410-10MGSize: 10 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-410-10MGSize:10 mg
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Background
Clinically, lenalidomide has proven to be effective in the treatment of multiple myeloma and other B cell diseases. It has the ability to selectively bind and ubiquitinate two lymphoid transcription factors, IKZF1 and IKZF2, via the CRBN-CRL4 ubiquitin ligase. This ultimately leads to the degradation of IKZF1 and IKZF2, which are both essential in myeloma cell survival.
Description
Ubiquitin ligase inducer
CAS Number
191732-72-6
Product Name Alternative
3- (7-amino-3-oxo-1H-isoindol-2-yl) piperidine-2,6-dione
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cell Signaling | Post-translational Modifications
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.01
Format
Powder
Solubility
Soluble in DMSO (200 mM), Water (<1 mM) and Ethanol (<1 mM).
Molecular Formula
C13H13N3O3
Molecular Weight
259.26
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Krönke J., et al. (2014) Science. 343(6168): 301-5. 2. Lu G., et al. (2014) Science. 343(6168): 305-9.

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