Niclosamide

• Background:

  Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.

• Description:

  Autophagy inducer

• Product Name Alternative:

  5-Chloro-N- (2-chloro-4-nitrophenyl) -2-hydroxybenzamide

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Autophagy

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  1

• Format:

  Pale yellow solid

• Solubility:

  Soluble to 25 mM in ethanol and to 10 mM in DMSO

• Molecular Formula:

  C13H8Cl2N2O4

• Molecular Weight:

  327.12

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.

• CAS Number:

  50-65-7