Niclosamide

• Background :

  Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.

• Description :

  Autophagy inducer

• Product Name Alternative :

  5-Chloro-N- (2-chloro-4-nitrophenyl) -2-hydroxybenzamide

• UNSPSC :

  41116105

• Type :

  Inducer

• Source :

  Synthetic

• Field of Research :

  Cancer | Autophagy

• Purity :

  >98% (TLC) ; NMR (Conforms)

• Weight :

  1

• Format :

  Pale yellow solid

• Solubility :

  Soluble to 25 mM in ethanol and to 10 mM in DMSO

• Molecular Formula :

  C13H8Cl2N2O4

• Molecular Weight :

  327.12

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.

• CAS Number :

  50-65-7