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Chloroquine diphosphate

CAT: 0400-SIH-405-1GSize: 1 gDry Ice: NoHazardous: No
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CAT#:0400-SIH-405-1GSize:1 g
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Background
Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.
Description
Autophagy inhibitor
CAS Number
50-63-5
Product Name Alternative
N4- (7-Chloro-4-quinolinyl) -N1, N1-dimethyl-1,4-pentanediamine diphosphate salt
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
1
Format
Beige Solid
Solubility
May be dissolved in water (25mg/mL)
Molecular Formula
C18H26ClN3·2H3PO4
Molecular Weight
515.86
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14. 2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.

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