Chloroquine diphosphate

• Background :

  Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.

• Description :

  Autophagy inhibitor

• Product Name Alternative :

  N4- (7-Chloro-4-quinolinyl) -N1, N1-dimethyl-1,4-pentanediamine diphosphate salt

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Autophagy

• Purity :

  >98% (HPLC) ; NMR (Conforms)

• Weight :

  1

• Format :

  Beige Solid

• Solubility :

  May be dissolved in water (25mg/mL)

• Molecular Formula :

  C18H26ClN3·2H3PO4

• Molecular Weight :

  515.86

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14. 2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.

• CAS Number :

  50-63-5