AICAR

• Background:

  AICAR is an adenosine analog that when phosphorylated forms 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5'-monophosphate (ZMP) which proceeds to activate adenosine monophosphate-activated protein kinase (AMPK). This process in turn stimulates glucose uptake by skeletal muscle in an insulin-dependent manner. Autophagy is initiated by the UNC-51-like kinase 1/2 complex (ULK1 and ULK2). Under basal conditions, autophagy is negatively regulated due to the phosphorylation of ULK1 at serine-757 by mTORC1. During starvation, autophagy is positively regulated by ULK1/2 when it is phosphorylated at serine-555 and serine-777 by AMPK. Therefore, the activation of AMPK by AICAR, in turn will induce autophagy.

• Description:

  Autophagy inducer

• Product Name Alternative:

  N1- (β-D-Ribofuranosyl) -5-aminoimidazole-4-carboxamide

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Autophagy

• Purity:

  >99% (TLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  Off-white solid.

• Solubility:

  Soluble to 75 mM in water and to 75 mM in DMSO.

• Molecular Formula:

  C9H14N4O5

• Molecular Weight:

  258.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Jhun B.S., et al. (2004) Biochem Biophys Res Commun. 318(2): 372-80. 2. Huang H., et al. (2013) Autophagy. 9(2): 175-95.

• CAS Number:

  2627-69-2