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Thapsigargin

CAT: 0400-SIH-399-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-399-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Thapsigargin is a cell-permeable inhibitor of the sarco-endoplasmatic reticulum Ca2+-ATPase (SERCA). This inhibition causes the release of intracellular Ca2+ stores. Thapsigargin also inhibits autophagy. This is due to the induction of and an ER stress response, which causes downstream effects that include an accumulation of autophagosomes in the cytosol. These intermediate structures never mature into amphisomes and autolysosomes, and the autophagy process cannot be completed.
Description
Autophagy inhibitor
CAS Number
67526-95-8
Product Name Alternative
(3S,3aR,4S,6S,6AR,7S,8S,9bS) -6- (Acetyloxy) -2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[ (2Z) -2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4- (1-oxobutoxy) azuleno[4,5-b]furan-7-yl octanoate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Colorless wax or white solid.
Solubility
Soluble in DMSO (65mg/mL); or Ethanol (20mg/mL)
Molecular Formula
C34H50O12
Molecular Weight
650.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Canová N.K., et al. (2007) Cell Biol Toxicol. 23(5): 337-54. 2. Ganley I.G., et al. (2011) Autophagy. 7(11): 1397-9. 3. Cheng Y., et al. (2013) Autophagy. 9(2): 208-19.

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CatalogName
TBZ1976Thapsigargin

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