Dihydroceramide

CAT: 0400-SIH-398-5MGSize: 5 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-398-5MGSize:5 mg
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Background
Both in yeast and mammalian systems, dihydroceramide is the reaction intermediate found immediately prior to the final reaction product in the de novo synthesis of ceramide lipids. Recent studies have revealed that an accumulation of dihydroceramide will induce autophagy. Accumulation of dihydroceramide occurs due to inhibition of dihydroceramide desaturase, the enzyme responsible for the conversion of dihydroceramide into ceramide.
Description
Autophagy inducer
CAS Number
13031-64-6
Product Name Alternative
C2 Dihydroceramide, D-erythro-N-Acetylsphinganine
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
≥98%
Weight
0.005
Format
White solid.
Solubility
Soluble in ethanol (5 mg/ml) or DMSO (5 mg/ml: dissolve in hot DMSO, then cool to RT).
Molecular Formula
C20H41NO3
Molecular Weight
343.54
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gagliostro, V. et al. (2012). Int J Biochem Cell Biol, 44(12): 2135-43. 2. Jiang, Q. et al. (2012). Int J Cancer, 130(3): 685-93. 3. Signorelli, P. et al. (2009). Cancer Lett, 282(2): 238-43.

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