Tunicamycin

• Background:

  As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy (1-4). Triggers a-synuclein oligomerization, dopaminergic neurons death and locomotor impariement, potentially a model for Parkinson's Disease (5).

• Description:

  Autophagy inducer

• Product Name Alternative:

  Tunicamycin from Streptomyces sp.

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Isolated from Streptomyces lysosuperficus

• Field of Research:

  Cancer | Autophagy | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein

• Purity:

  >98% (HPLC) as a mixture of tunicamycin A, B, C and D

• Weight:

  0.025

• Format:

  White solid.

• Solubility:

  Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).

• Molecular Formula:

  C39H64N4O16

• Molecular Weight:

  844.95

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14. 2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10. 3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12. 4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35. 5. Coppola-Segovia V., et al. (2016) Molecular Neuro. 54, 5798-5806.

• CAS Number:

  11089-65-9