Products for Research Use Only
RegisterLogin

Wortmannin

CAT: 0400-SIH-392-1MGSize: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0400-SIH-392-1MGSize:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
Description
Autophagy inhibitor
CAS Number
19545-26-7
Product Name Alternative
SL-2052, KY12420
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
≥98%
Weight
0.001
Format
White to off-white solid.
Solubility
Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).
Molecular Formula
C23H24O8
Molecular Weight
428.44
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23. 2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61. 3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4. 4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.

Alternative Products

CatalogName
XW176913-01Wortmannin

Popular Products