Bafilomycin A1

• Background :

  Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.

• Description :

  Autophagy inhibitor

• Product Name Alternative :

  (3Z,5E,7R,8S,9S,11E,13E,15S,16R) -8-Hydroxy-16-[ (1S,2R,3S) -2-hydroxy-1-methyl-3-[ (2R,4R,5S,6R) -tetrahydro-2,4-dihydroxy-5-methyl-6- (1-methylethyl) -2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Autophagy

• Purity :

  >98% HPLC; NMR (Conforms)

• Weight :

  0.0001

• Format :

  White powder to colorless film.

• Solubility :

  May be dissolved in DMSO (50mg/mL)

• Molecular Formula :

  C35H58O9

• Molecular Weight :

  622.84

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212. 2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16. 3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.

• CAS Number :

  88899-55-2